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Why do mosquito bites itch?

Mosquitos have a long mouthpart (proboscis) that extends far beyond their heads. It looks like a tiny needle. When a mosquito bites you, it uses this mouthpart to pierce your skin, suck your blood and secrete saliva into your bloodstream. When a mosquito secretes saliva into your bloodstream, your body registers the saliva as an allergen. Your immune system then sends the chemical histamine to the area where the mosquito bit you to remove the allergen from your body. Histamine is what causes your mosquito bites to itch and swell.

Source: Cleveland Clinic

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